The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram, escitalopram and fluoxetine (Prozac), venlafaxine and duloxetine are treatments of first line for anxiety disorders. Exercise and psychotherapy are also crucial for people suffering from anxiety. Antihistamines like hydroxyzine (Atarax Vistaril, Atarax) are prescribed by a few doctors.